What is the ONE Program?

The opioid misuse crisis has swept across the U.S. and our communities in the past decade. As many as one in four patients receiving long-term opioid therapy in a primary care setting struggles with opioid addiction. 1,2,3

It is important that opioid misuse prevention be moved upstream, to the initial patient encounter. In response to this challenge, faculty members at the NDSU School of Pharmacy and other partners introduced ONE Program, a three-hour continuing education seminar and patient care process.

The purpose is to equip pharmacists with tools to screen for opioid use disorder to identify patient needs and provide counseling and support to assist them in safely using prescribed opioids.



  • The science of addiction
  • An introduction to a tool to screen patients for risk of opioid misuse4
  • Risks associated with accidental opioid overdose
  • Naloxone prescribing, dispensing and consulting
  • Consultation on the risk of opioid misuse exemplified through lecture and role-play
  • A list of support services in the community for individuals concerned about an opioid use disorder is provided to pharmacists to disseminate to patients
  • Acknowledgements: Funding for the design and delivery of the ONE Program and pilot was provided by the North Dakota Department of Human Services, Alex Stern Family Foundation, ND Blue Cross Blue Shield Caring Foundation, FM Area Foundation, and the ND Board of Pharmacy.
    1. Banta-Green CJ, Merrill JO, Doyle SR, Boudreau DM, Calsyn DA. Opioid use behaviors, mental health and pain—development of a typology of chronic pain patients. Drug Alcohol Depend 2009;104:34–42.
    2. Boscarino JA, Rukstalis M, Hoffman SN, et al. Risk factors for drug dependence among out-patients on opioid therapy in a large US health-care system. Addiction 2010;105:1776–82.
    3. Fleming MF, Balousek SL, Klessig CL, Mundt MP, Brown DD. Substance use disorders in a primary care sample receiving daily opioid therapy. J Pain 2007;8:573–82.
    4. Webster LR, Webster R. Predicting aberrant behaviors in Opioid-treated patients: preliminary validation of the Opioid risk tool. Pain Med. 2005;6(6):432.
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